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KMID : 0043319950180020075
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Archives of Pharmacal Research
1995 Volume.18 No. 2 p.75 ~ p.78
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Stability of antineoplaston A10 in Aqueous Solution
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Oh In-Joon
Shin Sang-Chul
Lee Yong-Bok
Choi Bo-Gil
Lee Jeong-Min
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Abstract
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The analysis method nad stability test of antineoplaston A10, a new anticancer drug candidate, were established. A10 and phenylacetyl- L-glutamine, one of the degradation products, can be detected by high-performance liquid chromatography. The degradation kinetics of antineoplaston A10 in aqueous solutions from pH 1 to 10 buffers were carried out at 40, 50 and 60.deg.C. Pseudo-first order kinetics were obtained throughout the entire pH ranges studied. The pH-rate profiles showed that antineoplaston A10 was very unstable in alkaline conditions and most stable at pH 4.
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KEYWORD
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Antineoplaston A10, Stability, Hydrolysis, Anticaner angent
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